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Standard licensed doses of H1-antihistamines are ineffective in completely relieving symptoms in many patients for whom increasing the dosage up to fourfold is recommended.
However, the guidelines do not offer any comparisons of individual drugs.
Can knowledge of basic pharmacokinetics and pharmacodynamics predict clinical effectiveness?
Even the best antihistamines do not offer anything in terms of permanent relief, nor do they relieve nasal congestion.Oral antihistamines are the most commonly prescribed allergy medication.
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